MSF is about to start a cholera vaccination for a community in Mayom, reaching over 20,000 people. South Sudan, 2025. © MSF
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South Sudan: Cholera crisis is a symptom of deeper failures

A year-long cholera outbreak exposes the deadly cost of underfunding, displacement and violence.

Ilse De Boer
Deputy medical coordinator

I have spent a year watching cholera, a treatable disease, chew through South Sudan. And the hardest question isn’t how to treat it – we know how. The hardest question is this: Why hasn’t the outbreak been contained? Why, one year after the outbreak was declared on Oct. 28, are we still responding to a preventable disease that has already stolen over 1,500 lives and sickened over 93,000 people? 

The harsh reality is that the cholera epidemic is a symptom of South Sudan’s deepest vulnerabilities: systemic neglect, incessant violence and a fragile, underfunded healthcare system, resulting in significant service delivery gaps and lack of proper response. The scale of the outbreak is the result of a slow, underperforming and uncoordinated response – which has been a challenge since it began.

The withdrawal of support from major donors – including United States Agency for International Development (USAID) – has forced the closure of some health facilities, eliminating crucial lifelines.

As MSF’s deputy medical coordinator in South Sudan, I was directly involved in leading our medical response. Our priority was setting up cholera treatment units and centres to ensure patients could get timely treatment. We started in Renk, in Upper Nile State in the north of South Sudan, then moved to Malakal and Ulang, followed by Bentiu in Unity State and the capital, Juba. Over the next few months, our efforts rapidly expanded to numerous other areas across the country, allowing us to treat more than 35,000 people.

MSF’s cholera treatment unit in Abyei. South Sudan, 2025. © MSF

A worrying connection between underfunding, displacement and violence

At the heart of this crisis is the fragile nature of South Sudan’s public healthcare system, which depends almost entirely on external support. With the government allocating less than two per cent of its budget to health in recent years, the system is incapable of catering to the routine needs of its people, let alone a robust emergency response.  

Moreover, existing programs are on a precarious footing as a result of long-standing challenges, including insufficient domestic and international funding and critical implementation failures. The withdrawal of support from major donors – including United States Agency for International Development (USAID) – has forced the closure of some health facilities, eliminating crucial lifelines.  

In Bentiu, for instance, we witnessed how the reduction in funding to organizations that run water and sanitation and primary healthcare have left major gaps in the response, leaving people at risk while desperately searching for care. 

Added to this is the influx of people who have fled to South Sudan from Sudan, increasing the burden on limited services at a time when the country is facing reduced services due to funding cuts. Since April 2023, when the civil war in Sudan broke out, more than one million people have found refuge in South Sudan, equivalent to 10 per cent of the country’s population.  

Displaced people are often cut off from essential services, including vaccination programs, increasing their risk of both contracting and spreading cholera. The situation in transit camps in Renk – which now host more than three times their capacity – illustrates the crisis perfectly. 

This overcrowding, combined with poor water and sanitation and limited access to clean water, creates the perfect environment for disease to spread. It’s no surprise that this has driven the rise in other new waterborne diseases such as hepatitis E – a severe threat, especially to pregnant women.

People wash their hands before entering Ameth Bek hospital in Abyei as a means of disease prevention. South Sudan, 2025. © MSF

Attacks on healthcare and the impact of violence and insecurity

Perhaps the cruellest obstacle is the pervasive violence, insecurity and attacks on healthcare.  

A heartbreaking example occurred in March 2025, when fighting in Ulang forced dozens of patients to flee from the MSF hospital, including more than 30 patients receiving treatment for cholera treatment. The patients fled into the community, not only facing the risk of death themselves, but also fuelling the spread of the disease. The hospital would later be closed permanently because of looting.  

Since the start of 2025, MSF has been directly targeted in more than eight attacks, forcing the closure of another hospital in Old Fangak, Jonglei State, and reducing or suspending activities in others. As a result, hundreds of thousands of people have been cut off from healthcare.

Nyakuola Nguot Gang holds her newborn daughter who she delivered under MSF’s care. A mother of six, Nyakuula caught hepatitis E while pregnant with her youngest child in 2024. She had received the first dose of the multi-dose vaccine, providing partial protection. “Because of MSF, I received treatment. If it weren’t for them, I wouldn’t be here today. I was close to losing my life,” Nyakuola says. South Sudan, 2025. © MSF 
MSF staff unload cargo flown in from Juba to support operations in the remote area of Mayom. South Sudan, 2025. © MSF

Way forward: from crisis to responsibility

We know how to prevent cholera. It’s not a mystery. But until the government, the international community and all parties face up to their failures and ensure a unified, multi-sectoral and sustained response, we are simply waiting for the next outbreak. 

The government must step up and take responsibility for the care of its people. This includes scaling up emergency preparedness and response capacities and prioritizing service delivery in hot spot locations. 

The international community must provide renewed humanitarian and development support, not only to try and close the massive gaps left by recent funding cuts but also to ensure a more effective humanitarian response with the limited resources that remain. This includes scaling up sustainable programs for water and sanitation services and widespread vaccination for both cholera and hepatitis E. 

Finally, all parties to ongoing conflict must respect international humanitarian law and guarantee safe access to people in need. 

Without this fundamental shift, new outbreaks will continue to occur, condemning the people of South Sudan to a bleak future of avoidable suffering.